Benzoyl isothiocyanate → t-Butyl 3-amino-2-(N-benzoylthiocarbamoyl)crotonate

Participants

Reaction Steps

A mixture of t-butyl 3-aminocrotonate (65.3 g, 0.4 mol), benzoyl isothiocyanate (62.9 g, 0.4 mol), and diethyl ether (300 ml) was stirred at ambient temperature for 3 hours. The solid product was collected on a filter, washed with ether and dried to give 56 g (43.7 percent yield) of material melting at 107° to 110° C.

Provenance & Evidence