Sodium Hydroxide → HCID 20500783, compound

HRID 851668Notes

Reaction equation

HRID 851668 reaction equation
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:23][CH:22]=1)[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[OH-].[Na+]>CO>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]([N:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:25][CH:26]=2)=[O:20])=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53791652HCID 53791652, compound

Product 1

HCID 20500783HCID 20500783, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described in example 1(b), the reaction is carried out with 7.4 g (15 mmol) of 8-[4-chloro-N-(4-benzyloxyphenyl)-benzamido]-caprylic acid methyl ester, 1 g (23 mmol) of sodium hydroxide and 200 cc. of methanol. Reaction time: 48 hours, reaction temperature: 25° C. The crude product is used in the next reaction step without further purification.

Workup

  1. customReaction time
  2. custom48 hours, reaction temperature
  3. custom25° C

Sources & evidence

ORD record
ord-e7d3ccae346e4d10b18efe7f08a4fb72
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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