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HRID851676

反应详情

EQUATION

反应方程式

HRID 851676 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)OC[C@H]1O[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCNC(=O)CCS[C@@H]2O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)NC(=O)CCS[C@@H]2O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)C(=O)O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O.N#N
HCID86738903

未命名化合物

PRODUCTS

生成物

1
结构：N#N.O=C(CCS[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NCCCC[C@H](NC(=O)[C@H](CCCCNC(=O)CCS[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(=O)CCS[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)C(=O)O
HCID86738902

未命名化合物

收率 61%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC.CO.O
溶剂HCID23434731

未命名化合物

PROCEDURE

实验过程

A solution of 19 (50 mg) in methanol-water-triethylamine 5:4:1 (v/v/v, 2 ml) was kept for 18 hours at room temperature, and evaporated in vacuo to dryness. The residue was put on a column of silica gel and eluted with chloroform-methanol-water 60:40:10 (v/v/v). The title compound was isolated in 61% yield (20 mg): RF 0.15 (CHCl3 -MeOH-H2O, 60:40:10); NMR (D2O)δ: 4.51 (d, J1,2 =9.5 Hz, 2H, H-1), 4.52 (d, J1,2 =9.5 Hz, 1H, H-1), 4.34, 4.18 (q, q, α-CH), 3.99 (d, J4,3 =3.0 Hz, 3H, H-4), 3.22 (m, εCH2), 3.02 (m, SCH2), 2.70 (t, J=6.5 Hz, 2H, SCH2CH2), 2.62 (t, J=6.5 Hz, 4H, SCH2CH2); [α]D27 -17.3° (c 1.5, H2O).

WORKUP

后处理

  1. customevaporated in vacuo to dryness
  2. washeluted with chloroform-methanol-water 60:40:10 (v/v/v)