73181-69-8 → HCID 178481104, compound

HRID 851693Notes

Reaction equation

HRID 851693 reaction equation
[C:1]([O:5][C:6]([N:8]=[C:9]1[NH:13][C:12]([C:14](=O)[C:15]([OH:17])=[O:16])=[CH:11][S:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:19][N:20]1[CH2:24][CH2:23][N:22]([CH3:25])[C:21]1=[O:26]>C(O)C>[C:1]([O:5][C:6]([N:8]=[C:9]1[NH:13][C:12]([C:14](=[N:19][N:20]2[CH2:24][CH2:23][N:22]([CH3:25])[C:21]2=[O:26])[C:15]([OH:17])=[O:16])=[CH:11][S:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 2050091773181-69-8HCID 178453003HCID 178453003, compound

Product 1

HCID 178481104HCID 178481104, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

13.1 g of 2-(2-tert.-butoxycarbonylimino-4-thiazolin-4-yl)-glyoxylic acid are dissolved in 160 ml of ethanol by warming for a short time. 5.5 g of 1-amino-2-oxo-3-methyl-imidazolidine are added to this solution at 20° C. After standing overnight, the reaction mixture is evaporated in a rotary evaporator, the residue is treated with water and the precipitate is filtered off. Excess NaHCO3 solution is added to this precipitate and the undissolved material is filtered off. The filtrate is acidified and the precipitate which separates out is filtered off, washed with water and dried.

Workup

  1. temperatureby warming for a short time
  2. customthe reaction mixture is evaporated in a rotary evaporator
  3. additionthe residue is treated with water
  4. filtrationthe precipitate is filtered off
  5. additionExcess NaHCO3 solution is added to this precipitate
  6. filtrationthe undissolved material is filtered off
  7. filtrationthe precipitate which separates out is filtered off
  8. washwashed with water
  9. customdried

Sources & evidence

ORD record
ord-c735dff80d424b58ab44174da8a9499c
Source dataset
uspto-grants-1983_05
Patent number
US04386089

Reaction notes

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