HCID 54324563, compound → HCID 22823316, compound

Participants

Reaction Steps

4.75 g (10 mmoles) of Z-Glp-Nva-Ile-NH2 are dissolved in 200 ml of acetic acid, 1 g of a 10% palladium-on-carbon catalyst is added, and hydrogen is bubbled through the mixture for one hour. The catalyst is filtered off, the filtrate is evaporated, and the residue is triturated with ether. 3.34 g (98%) of Glp-Nva-Ile-NH2 are obtained; m.p.: 267°-270° C. (decomposition), Rf5 =0.61, [α]D25 =-50.2° (c=1%, in acetic acid).

Provenance & Evidence