Ethanol → HCID 13229101, compound

Participants

Reaction Steps

A solution of 28.3 g of 2-(1,2,3,4-tetrahydro naphthalene 1-one 3-yl)acetic acid (VIII) in 150 ml of ethanol, 30 ml of 7 N hydrochloric ethanol and 150 ml of benzene is brought to reflux for 8 hours. Then the solvents are evaporated, the residue is taken up in ether, washed with water, dried on sodium sulfate, filtered and the filtrate evaporated. 38 g (Yield ~100%) of 2-(1,2,3,4-tetrahydro naphthalene 1-one 3-yl)acetic acid ethyl ester are obtained, the NMR spectrum of which has the following characteristics: δppm=7.8 to 8.1, m (aromatic H at 8); 7.2 to 7.6, m (aromatic H at 5, 6 and 7); 4.15, q (COO--CH2); 2.4 to 3, m (7 H: protons at 2,3,4 and CH2 --CO--O--); 1.25, t (CH3).

Provenance & Evidence