反应详情

Sulphuryl chloride (16.0 ml.) was added during 10 minutes to a stirred mixture of 1'-(3,4-dichlorobenzyl)-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (28.2 g.) in acetic acid (400 ml.). The mixture obtained was then stirred at 60°-65° C. for 40 minutes. The clear solution which formed was poured into water (3 l.). The solid which was precipitated was collected by filtration, washed with water and air-dried. Recrystallisation of the crude solid thus obtained from aqueous propan-2-ol gave 5'-chloro-1'-(3,4-dichlorobenzyl)-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (15.4 g.), m.p. 257°-259° C.

1. customThe mixture obtained
2. customThe clear solution which formed
3. customThe solid which was precipitated
4. filtrationwas collected by filtration
5. washwashed with water
6. customair-dried
7. customRecrystallisation of the crude solid
8. customthus obtained from aqueous propan-2-ol