1,2-Dimethoxyethane → HCID 20501025, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl chloroformate (1.1 g.) was added to a stirred mixture of 1'-(3,4-dichlorobenzyl)-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (1.8 g.) and sodium carbonate (2.0 g.) in dimethoxyethane (60 ml.). The mixture was stirred at 25° C. for 16 hours. The solid was removed by filtration and the filtrate was evaporated. The residue obtained was recrystallised twice from ethyl acetate/petrol 60-80 to give 1'-(3,4-dichlorobenzyl)-1,3-di(ethoxycarbonyl)-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (0.6 g.), m.p. 180°-182° C.

Provenance & Evidence