反应详情

0.728 g (2 mmole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone and 0.560 g (5 mmole) of potassium tert-butoxide in 8 ml of toluene were heated to reflux for 1 hour in a reaction vessel fitted with a water separator. After cooling to 10°, addition of water (15 ml), extraction with ether (2×15 ml), washing of the organic layer with brine (15 ml), then with water, drying over Na2SO4, evaporation and final distillation (0.02 Torr--bath temperature: 140°) there were isolated 0.340 g (83% yield) of the desired compound.

1. temperatureto reflux for 1 hour in a reaction vessel
2. temperatureAfter cooling to 10°
3. washwashing of the organic layer with brine (15 ml)
4. dry with materialwith water, drying over Na2SO4, evaporation
5. distillationfinal distillation (0.02 Torr--bath temperature: 140°) there