反应详情

29.0 ml of a 30% solution of sodium methoxide in methyl alcohol (0.15 mole) were added dropwise to a mixture of 36.4 g (0.10 mole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone and 200 ml of toluene, kept at reflux in a reaction vessel fitted with a water separator (addition period: ca. 1 hour). After this first addition, 14.6 g (0.13 mole) of potassium tert-butoxide were added to the reaction mixture, which was then heatedd to reflux during 4 hours. After the usual treatments of extraction and distillation, there were isolated 17.1 g (84% yield) of the desired compound.

1. temperatureat reflux in a reaction vessel
2. additionwere added to the reaction mixture, which
3. temperatureto reflux during 4 hours
4. extractionAfter the usual treatments of extraction and distillation