Benzoic acid, 2-amino-5-fluoro-3-nitro- (9CI) → 2,3-Diamino-5-fluoro-benzoic acid

Participants

Reaction Steps

2-Amino-5-fluoro-3-nitrobenzoic acid (142; 0.73 g) was dissolved into methanol (10 mL). To this solution was added 5% Pd/C (0.1 g). The resulting reaction mixture was stirred at room temperature under 1 atm of hydrogen for 18 h and then filtered through a pad of Celite. The filtrate was concentrated under reduced pressure to afford 2,3-diamino-5-fluorobenzoic acid 143 as a brown solid (0.59 g, 95%).

Provenance & Evidence