Dimethyl Sulfoxide → HCID 54150769, compound

HRID 851821Notes

Reaction equation

HRID 851821 reaction equation
C(S([CH2:8][CH2:9][CH2:10][CH:11]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:12]1=O)(=O)=O)CCC.[OH-].[K+].CS(C)=O>C1(C)C=CC=CC=1>[C:11]12[CH2:10][CH2:9][CH:8]=[C:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]=2

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 14797Potassium HydroxideHCID 20501205HCID 20501205, compound

Product 1

HCID 54150769HCID 54150769, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

10 g (0.029 mole) of 2-(3-n-butylsulfonyl-prop-1-yl)-cyclododecanone in 40 ml of toluene were heated to reflux for 30 min. in the presence of powdered KOH, in accordance with the process of Example 1, letter (b). After addition of 6 ml of DMSO, heating to reflux for 12 further hours and usual treatments of extraction and distillation as previously described, the desired title compound was isolated in a 84% yield.

Workup

  1. temperatureheating
  2. temperatureto reflux for 12 further hours and usual treatments of extraction and distillation

Sources & evidence

ORD record
ord-a912f43f95b841c5b42aa83ea9f27ace
Source dataset
uspto-grants-1983_05
Patent number
US04386220

Reaction notes

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