Ethane, 1-chloro-2-ethoxy- → 1-(2-Ethoxyethyl)-2-ethyl-1H-benzimidazole

HRID 851843Notes

Reaction equation

HRID 851843 reaction equation
[CH2:1]([C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[CH3:2].[CH2:12]([O:14][CH2:15][CH2:16]Cl)[CH3:13]>>[CH2:12]([O:14][CH2:15][CH2:16][N:7]1[C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]=[C:3]1[CH2:1][CH3:2])[CH3:13]

Participants

3

Reactant 2

HCID 12341Ethane, 1-chloro-2-ethoxy-HCID 158072-Ethylbenzimidazole

Product 1

HCID 31553141-(2-Ethoxyethyl)-2-ethyl-1H-benzimidazoleYield 80%

Procedure

1-(2-Ethoxyethyl)-2-ethyl-1H-benzimidazole was synthesized as in Synthesis Example 1 except that an equimolar amount of 2-ethylbenzimidazole was used instead of benzimidazole, and an equimolar amount of 2-chloroethyl ethyl ether was used instead of 2-chloroethyl methyl ether. Yield 80%.

Sources & evidence

ORD record
ord-234d20701a58422ca6165bef468e4a83
Source dataset
uspto-grants-2007_08
Patent number
US07252925B2

Reaction notes

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