Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 851849Generated: October 25, 2026

(6Rs,7rs)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-2(1h)-one → (6Rs,7rs)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2h)-one

https://huagongshe.com/reaction/851849

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(6Rs,7rs)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-2(1h)-oneHCID 69426524—
Reactant(6Rs,7rs)-3,5,5,6,7,8,8-heptamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2h)-oneHCID 69429922—
Product(6Rs,7rs)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2h)-oneHCID 69428735—

Reaction Steps

The addition of 100 parts by weight of (6RS,7RS)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2H)-one to the above-described eau de toilette imparted to the latter a powerful musky and earthy connotation, having also a well appreciated aspect which is slightly ambrette and pine. The overall effect was in-between the one which could have been brought by the addition of CASHMERAN® or TONALIDE®, however the substantivity was by far superior to that which could have been imparted by the addition of CASHMERAN®, and its musky-ambrette character was more elegant than the one provided by TONALIDE®. The addition of (6RS,7RS)-3,5,5,6,7,8,8-heptamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2H)-one or (6RS,7RS)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-2(1H)-one, instead of (6RS,7RS)-5,5,6,7,8,8-hexamethyl-3,4,5,6,7,8-hexahydronaphthalen-1(2H)-one, to the above-described eau de toilette provided a more classic fragrance, wherein the earthy-woody effect was more pronounced than the one which could have been obtained by the addition of TONALIDE®.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07253141B2
Source datasetuspto-grants-2007_08
ORD IDord-b0656690d2bb42239c1c4b279e07a7b9
Source noteuspto-grants-2007_08