2-Nitroresorcinol → 2-Aminoresorcinol

HRID 851861Notes

Reaction equation

HRID 851861 reaction equation
[N+:1]([C:4]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:5]=1[OH:6])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:5]=1[OH:6]

Participants

4

Reactant 1

HCID 117602-Nitroresorcinol

Product 1

HCID 694512-AminoresorcinolYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Nitroresorcinol (1.00 g, 6.45 mmol) was dissolved in ethanol (10 mL). The solution was then stirred for 6 hours at room temperature in the presence of 10% Pd/C (340 mg, 0.32 mmol) under hydrogen gas atmosphere. Insolubles were removed by filtration, and the solvent was distilled off under reduced pressure, to give 779 mg (yield 97%) of the desired compound in the form of a brown crystalline product.

Workup

  1. customInsolubles were removed by filtration
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-550fb20a8dc44c6884b7407be3d69e6e
Source dataset
uspto-grants-2007_08
Patent number
US07253154B2

Reaction notes

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