HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl hydrogen 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate | HCID 86760522 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | Ethyl hydrogen 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate | HCID 10151118 | — |
Reaction Steps
0.66 mmol of the product of Example 52 in 3 ml of 1N NaOH is stirred for 8 h at 70° C. The reaction solution is acidified with 1N HCl and the white precipitate is filtered off to yield the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253161B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-3f98485dd1754453a68a78d9cea4c689 |
| Source note | uspto-grants-2007_08 |