Water → HCID 12157386, compound

HRID 851880Notes

Reaction equation

HRID 851880 reaction equation
B(Br)(Br)Br.[CH3:5][O:6][C:7]1[CH:21]=[CH:20][C:10]2[N:11]3[CH2:19][CH2:18][CH2:17][C:12]3=[N:13][S:14](=[O:16])(=[O:15])[C:9]=2[CH:8]=1.[OH2:22]>C(Cl)Cl>[O:15]=[S:14]1(=[O:16])[C:9]2[CH:8]=[C:7]([O:6][C:5]3[CH:9]=[C:8]([OH:22])[CH:7]=[CH:21][CH:20]=3)[CH:21]=[CH:20][C:10]=2[N:11]2[CH2:19][CH2:18][CH2:17][C:12]2=[N:13]1

Participants

5

Reactant 3

HCID 962WaterHCID 25134Boron tribromideHCID 11253769HCID 11253769, compound

Product 1

HCID 12157386HCID 12157386, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 68.75 mmol of BBr3 in 25 ml of methylene chloride is added dropwise to a solution, cooled to 0° C., of 27.50 mmol of 7-methoxy-2,3-dihydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide in 350 ml of methylene chloride. Stirring is carried out at ambient temperature for 24 hours. The reaction mixture is poured into a mixture of ice and water, and the suspension is stirred for 30 minutes. The precipitate is filtered off, rinsed several times with water, filtered under suction and dried in vacuo to yield the expected product.

Workup

  1. stirringthe suspension is stirred for 30 minutes
  2. filtrationThe precipitate is filtered off
  3. washrinsed several times with water
  4. filtrationfiltered under suction
  5. customdried in vacuo

Sources & evidence

ORD record
ord-c1eaf65283c048ba94d3cea6f186348b
Source dataset
uspto-grants-2007_08
Patent number
US07253163B2

Reaction notes

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