Ethanol → HCID 69413843, compound

HRID 851881Notes

Reaction equation

HRID 851881 reaction equation
[NH:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:25]=[CH:26][CH:27]=2)[O:9][C:10]2[CH:24]=[CH:23][C:13]3[N:14]4[CH2:22][CH2:21][CH2:20][CH:15]4[NH:16][S:17](=[O:19])(=[O:18])[C:12]=3[CH:11]=2)=[N:4][N:3]=[N:2]1.[CH2:28](O)C>>[CH3:28][N:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:25]=[CH:26][CH:27]=2)[O:9][C:10]2[CH:24]=[CH:23][C:13]3[N:14]4[CH2:22][CH2:21][CH2:20][C:15]4=[N:16][S:17](=[O:19])(=[O:18])[C:12]=3[CH:11]=2)=[N:4][NH:3][NH:2]1

Participants

3

Reactant 2

HCID 702EthanolHCID 178527154HCID 178527154, compound

Product 1

HCID 69413843HCID 69413843, compound

Procedure

200 μl (0.39 mmol) of bis(tri-n-butyl)tin oxide are added to a suspension of the product obtained in Example 1 (300 mg, 0.78 mmol) in 20 ml of anhydrous ethanol and the solution is refluxed for 10 minutes. The ethanol is evaporated off, 1 ml of methyl iodide is added and stirring is carried out at ambient temperature overnight. The precipitate is filtered off to yield a mixture of the 1- and 2-methyl-2H-tetrazol isomers which is purified to yield the title product.

Workup

  1. temperaturethe solution is refluxed for 10 minutes
  2. customThe ethanol is evaporated off
  3. addition1 ml of methyl iodide is added
  4. filtrationThe precipitate is filtered off
  5. customto yield
  6. customis purified

Sources & evidence

ORD record
ord-2030b33a041a4f49bdfdd212d6c4f174
Source dataset
uspto-grants-2007_08
Patent number
US07253163B2

Reaction notes

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