1,1'-Thiocarbonyldiimidazole → HCID 178527156, compound

Participants

Reaction Steps

To a suspension of the product obtained in Step A of Example 13 (300 mg, 0.81 mmol) in 6 ml of CH3CN there are added 239 mg (1.21 mmol) of thiocarbonyldiimidazole and then 481 μl (3.22 mmol) of DBU. The reaction solution is stirred at ambient temperature for 1 hour. Evaporation to dryness and chromatography on silica (CH2Cl2/MeOH 95/5) are carried out. After evaporating the fractions containing the product formed, the residue is triturated in MeOH and the title product is recovered by filtration.

Provenance & Evidence