HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)furan → 7-[3-(2-Furyl)phenoxy]-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)furan | HCID 4393688 | — |
| Reactant | 7-(3-bromophenoxy)-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide | HCID 69414589 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 7-[3-(2-Furyl)phenoxy]-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide | HCID 69414643 | — |
Reaction Steps
A suspension of the product obtained in Step A (200 mg, 0.50 mmol), 222 μl (0.66 mmol) of 2-(tributylstannyl)furan and 30 mg (0.025 mmol) of tetrakistriphenylphosphine in 4 ml of toluene is refluxed for 45 minutes. The toluene is evaporated off in vacuo and the residue is chromatographed on SiO2 (CH2Cl2/acetone 96/4) to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253163B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-6a982e73ef2243a795097b4f841f666c |
| Source note | uspto-grants-2007_08 |