Acetic Acid → HCID 69412878, compound

Participants

Reaction Steps

250 mg (0.75 mmol) of {3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]-benzothiadiazin-7-yl)oxy]phenyl}amine and 137 μl (1.06 mmol) of 2,5-dimethoxytetra-hydrofuran are added to a two-phase mixture of 2.5 ml of water, 1.25 ml of AcOH and 3.75 ml of dichloro-1,2-ethane. Stirring is carried out at 80° C. for 1 hour; the mixture is allowed to return to ambient temperature and is extracted with CH2Cl2. The organic phase is washed with saturated aqueous NaCl solution and dried over MgSO4. The title product is purified by chromatography on a silica column (CH2Cl2/heptane 70/30).

Provenance & Evidence