Sodium Iodide → HCID 69414185, compound

Participants

Reaction Steps

A mixture of 300 mg (0.90 mmol) of {3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenyl}amine, 192 mg of Na2CO3 (1.81 mmol), 5 mg of NaI, 126 μl of 2-bromoethyl ether (0.905 mmol) in 6 ml of CH3CN is refluxed overnight. The suspension is filtered; the filtrate is evaporated, taken up in CH2Cl2 and washed with saturated NaCl solution. After evaporation in vacuo, the expected product is purified by chromatography on silica (CH2Cl2/acetone 96/4).

Provenance & Evidence