Acetyl chloride → HCID 69197666, compound

HRID 851895Notes

Reaction equation

[C:1](Cl)(=[O:3])[CH3:2].Cl.[O:6]=[S:7]1(=[O:29])[C:12]2[CH:13]=[C:14]([O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][NH2:25])=[CH:20][CH:19]=3)[CH:15]=[CH:16][C:11]=2[N:10]2[CH2:26][CH2:27][CH2:28][CH:9]2[NH:8]1>>[O:29]=[S:7]1(=[O:6])[C:12]2[CH:13]=[C:14]([O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:1](=[O:3])[CH3:2])=[CH:20][CH:19]=3)[CH:15]=[CH:16][C:11]=2[N:10]2[CH2:26][CH2:27][CH2:28][CH:9]2[NH:8]1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 691992861-{4-[(5,5-Dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]-benzothiadiazin-7-yl)oxy]phenyl}methanamine hydrochloride

Product 1

HCID 69197666HCID 69197666, compound

Procedure

The procedure is as in Example 2, replacing the methanesulphonic anhydride by acetyl chloride and using as starting material the amine obtained in Example 20.

Sources & evidence

ORD record: ord-9d1843e50b1e4b4d8d67c27cb5c6cfc1
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253162B2

Reaction notes

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