HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 851897Generated: October 30, 2026
Hydrochloric Acid → HCID 178527155, compound
https://huagongshe.com/reaction/851897
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | {4-[(5,5-Dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenyl}acetonitrile | HCID 69199240 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178527155 | HCID 178527155 | — |
Reaction Steps
A suspension of 300 mg (0.844 mmol) of the product obtained in Step A, 164 mg (2.53 mmol) of sodium azide and 113 mg (2.11 mmol) of NH4Cl in 3 ml of DMF is stirred at 110° C. for 24 hours. The reaction mixture is allowed to return to ambient temperature and is poured into 20 ml of 1N HCl. Extraction (AcOEt), drying (MgSO4) and evaporating to dryness are carried out. The residue is triturated in Et2O and the precipitate is filtered off to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07253162B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-5fd29ee5980e434f944cdd8222fb58c5 |
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| Source note | uspto-grants-2007_08 |
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