Hydrochloric Acid → HCID 69523007, compound

Participants

Reaction Steps

To a suspension of the product obtained in Step C (1.40 g, 3.91 mmol) in 20 ml of CH2Cl2 there are added 2 drops of DMF and then, dropwise, 684 μl (7.81 mmol) of oxalyl chloride diluted with 2 ml of CH2Cl2. Stirring is carried out at ambient temperature for 2 hours 30 minutes; evaporation to dryness is carried out; the residue is taken up in 15 ml of CH2Cl2; 1.1 ml (7.81 mmol) of Et3N and then 2.94 ml (5.87 mmol) of a 2M solution of dimethylamine in THF are added. Stirring is carried out at ambient temperature for 1 hour. The reaction mixture is acidified with 0.5N HCl and extracted (CH2Cl2). The organic phases are combined, washed (saturated NaCl), dried (MgSO4) and evaporated. The residue is triturated in Et2O; the title product precipitates out and is recovered by filtration. Elemental micro-analysis:

Provenance & Evidence