HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl bromoacetate → (1-Tert-butoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | Methyl 2-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetate | HCID 21519358 | — |
| Product | (1-Tert-butoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-acetic acid methyl ester | HCID 69008131 | 89% |
Reaction Steps
Following a similar N-alkylation procedure described in example 6, the (2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-acetic acid methyl ester (0.99 mmol) is alkylated with tert-butyl bromoacetate to give (1-tert-butoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-acetic acid methyl ester as a colorless oil, after purification by silica gel chromatography (hexane/EtOAc). Yield: 89%. MS: (ES+): 356.2 [M+23].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253164B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-fcfe85a4540744cc900bfbe57f3352f8 |
| Source note | uspto-grants-2007_08 |