Triethylamine → HCID 69519922, compound

Participants

Reaction Steps

Pyrimidine-5-carboxylic acid (14.9 mg, 0.12 mmol), BOP (66.3 mg, 0.15 mmol), and Et3N (34.8 μL, 0.25 mmol) are added to a solution of (1S,4S)-2-[(S)-1-(4-methoxy-2,3-dimethylphenyl)-ethyl]-2,5-diazabicyclo[2.2.1]heptane (26 mg, 0.1 mmol) in anhydrous DMA (1 mL). The reaction mixture is stirred at room temperature for 16 h, diluted with EtOAc, washed with aqueous NaOH 1N (2×8 mL) and brine, dried with Na2SO4, filtered, and concentrated under reduced pressure. The residue is purified by preparative thin layer chromatography eluting with CH2Cl2-MeOH—NH4OH (90-9-1) to afford a yellow oil. LC/MS: 367 (M+1).

Provenance & Evidence