HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 5-Hydroxymethyl-pyridine-2-carboxylic acid cyclopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate | HCID 2733204 | — |
| Reactant | 5-(Hydroxymethyl)pyridine-2-carboxylic acid | HCID 13518563 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Hydroxymethyl-pyridine-2-carboxylic acid cyclopropylamide | HCID 69491453 | — |
Reaction Steps
5-Hydroxymethyl-pyridine-2-carboxylic acid (0.23 g, 1.5 mmol) was dissolved in DMF (3 ml) and activated with TPTU (0.45 g, 1.5 mmol), Hünig's base (0.51 ml, 3.0 mmol) and reacted with cyclopropyl amine (0.12 ml, 1.65 mmol) for 1 h at r.t during which a precipitate was formed. Solvent was removed and the residue dissolved in acetonitrile/water and purified by prep.RP(C18)HPLC: 60 mg;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253158B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-ecb1f1d616ea4181beade1ca658b9927 |
| Source note | uspto-grants-2007_08 |