Aluminium lithium hydride → HCID 69491132, compound

Participants

Reaction Conditions

Reaction Steps

To lithium aluminium hydride (0.03 g, 0.90 mmol) suspended in dry THF (1 ml) and cooled to 0° C. under an argon atmosphere was added a solution of 3-fluoro-4-(2-morpholin-4-yl-ethoxy)-benzoic acid ethyl ester (0.15 g, 0.5 mmol) in dry THF (1 ml). The cold bath was removed and the reaction mixture further stirred for 2 h at r.t. The reaction mixture was cooled (0° C.) and quenched with NaHCO3 (½ sat., 2 ml) and further stirred for 0.5 h at r.t., filtered and concentrated under reduced pressure. The filtrate was dissolved in ethyl acetate and washed with water (2×), brine, dried (MgSO4) filtered and concentrated under reduced pressure: 0.12 g (86%);

Provenance & Evidence