Hydrochloric Acid → HCID 11605550, compound

Participants

Reaction Conditions

Reaction Steps

Rac-4-Chloro-N-(4-cyano-benzyl)-N-(5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide (80 mg, 0.18 mmol) was dissolved in dimethylformamide (1 ml). Then ammonium chloride (11 mg, 0.2 mmol) and sodium azide (13 mg, 0.2 mmol) was added and the mixture was stirred overnight at 120° C. After cooling the mixture was distributed 3 times between ethyl acetate (10 ml) and hydrochloric acid (10 ml 1N). The combined organic layers were dried and evaporated. The residue was purified on silica gel (eluent hexane/ethyl acetate) to yield 79 mg (89%). MS: m/e=506.1 (M+NH4+).

Provenance & Evidence