反应详情

3-(4-{[(4-Chloro-benzenesulfonyl)-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-amino]-methyl}-phenyl)-propionic acid methyl ester (0.06 g, 0.11 mmol) was dissolved in methanol (4 ml) and treated with 1 N NaOH (0.2 ml) overnight. The mixture was diluted with water and the methanol removed under reduced pressure. The residue was acidified (KHSO4/K2SO4) and extracted with ethyl acetate (3×). The combined extracts were concentrated and the crude residue was purified using preparative RP(C18) chromatography: lyophilisate 15 mg; MS: m/e=491.1 (MH+).

1. customthe methanol removed under reduced pressure
2. extractionextracted with ethyl acetate (3×)
3. concentrationThe combined extracts were concentrated
4. customthe crude residue was purified