HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide → 3-(2-{[(4-chloro-benzenesulfonyl)-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-amino]-methyl}-5-fluoro-phenyl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide | HCID 69489220 | — |
| Reactant | 3-(2-Bromomethyl-5-fluoro-phenyl)-propionic acid methyl ester | HCID 69491357 | — |
| Product | 3-(2-{[(4-chloro-benzenesulfonyl)-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-amino]-methyl}-5-fluoro-phenyl)-propionic acid | HCID 69489225 | — |
Reaction Steps
4-Chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide was alkylated using 3-(2-bromomethyl-5-fluoro-phenyl)-propionic acid methyl ester analogous to Example 2c and then saponified to give 3-(2-{[(4-chloro-benzenesulfonyl)-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-amino]-methyl}-5-fluoro-phenyl)-propionic acid. MS: m/e=509.3 (MH−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253158B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-4d599c02badb41128f0e77b6ac70d017 |
| Source note | uspto-grants-2007_08 |