HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-(Bromomethyl)phenyl)isoxazole → 4-chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-(Bromomethyl)phenyl)isoxazole | HCID 22997545 | — |
| Reactant | 4-Chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide | HCID 69489220 | — |
| Product | 4-chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide | HCID 11684539 | — |
Reaction Steps
4-Chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-benzenesulfonamide was alkylated using 5-(4-bromomethyl-phenyl)-isoxazole analogous to Example 2c to afford 4-chloro-N-((R)-5,5-dimethyl-2-oxo-azepan-3-yl)-N-(4-isoxazol-5-yl-benzyl)-benzenesulfonamide MS: m/e=488.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253158B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-1bf0304e2ef44de9ba2c649dea768e81 |
| Source note | uspto-grants-2007_08 |