HCID 69507693, compound → HCID 44455497, compound

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4-({(4-Chloro-benzenesulfonyl)-[1-(2,4-dimethoxy-benzyl)-4,4-dimethyl-2-oxo-azepan-3-yl]-amino}-methyl)-N-cyclopropyl-benzamide (95 mg) was dissolved in a mixture of trifluoroacetic acid/trifluoromethanesulfonic acid/dichloromethane=40:1:59 (2 ml) and stirred at room temperature for 15 minutes. After evaporation flash chromatography (heptane/ethyl acetate gradient) yielded 65 mg (90%) of 4-{[(4-chloro-benzenesulfonyl)-(4,4-dimethyl-2-oxo-azepan-3-yl)-amino]-methyl}-N-cyclopropyl-benzamide as a foam; MS: m/e=504.2 (MH+), 521.3 (M+NH4+).

Provenance & Evidence