HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde oxime | HCID 21822251 | — |
| Product | 4,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile | HCID 4201620 | — |
Reaction Steps
4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde oxime (7.20 g, 30.38 mmol) was added to neat thionyl chloride (29.63 g, 245 mmol), then the mixture was heated to reflux for 4 hours. The reaction mixture was poured onto ice-water. The precipitate of 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile was collected and dried (Yield=6.15 g, 92%). 1H-NMR (300 MHz, CDCl3) δ 2.75(s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253174B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-b08741bb1e154e0e85c264356b98127b |
| Source note | uspto-grants-2007_08 |