HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 852042Generated: October 31, 2026
Neopentylamine → 3-[6-(2,2-Dimethyl-propylamino)-pyrimidin-4-ylamino]-4,N-dimethyl-benzamide
https://huagongshe.com/reaction/852042
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Neopentylamine | HCID 79882 | — |
| Reactant | 3-(6-Chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide | HCID 58928514 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[6-(2,2-Dimethyl-propylamino)-pyrimidin-4-ylamino]-4,N-dimethyl-benzamide | HCID 58928537 | 99% |
Reaction Steps
To a solution of 3-(6-chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide (0.4 g, 1.44 mmol) in DMSO (3 mL), neopentylamine (0.4 mL, 3.39 mmol) was added. The resulting solution was heated at 110° C. for 4 days. The product was purified by silica gel column chromatography using ethyl acetate as eluent to afford the product (0.45 g, yield 99%). MS (m/z): 328 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07253174B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-1f5666c6502b4edd9dabd5a855918399 |
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| Source note | uspto-grants-2007_08 |
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