HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 852045Generated: October 29, 2026
Diisopropylethylamine → 3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide
https://huagongshe.com/reaction/852045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2,2-Dimethylpropyl)(methyl)amine hydrochloride | HCID 22393520 | — |
| Reactant | 3-(6-Chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide | HCID 58928514 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide | HCID 58928505 | 99% |
Reaction Steps
To a solution of 3-(6-chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide (0.4 g, 1.44 mmol) in DMSO (3 mL), N-methylneopentylamine hydrochloride (0.4 g, 2.9 mmol) and DIEA (0.5 mL, 2.9 mmol) were added. The resulting solution was heated at 110° C. for 4 days. The product was purified by silica gel column chromatography using ethyl acetate as eluent to afford the product (0.46 g, yield 99%). MS (m/z): 342 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07253174B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-b934f416b3cc41249e103c06d9c88c24 |
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| Source note | uspto-grants-2007_08 |
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