Hydrochloric Acid → HCID 12111983, compound

Participants

Reaction Steps

To a suspension of ethyl 3-{2-[2-(2,4-dichlorophenoxy)ethoxy]-4-pyridyl}-2-isopropoxypropanoate (24 mg) in methanol (2 mL) was added 5N aqueous sodium hydroxide solution (0.4 mL), and the resulting solution was stirred at room temperature for 12 hours. The reaction solution was diluted with water, and adjusted to pH 5 with 5N hydrochloric acid. After extracting with ethyl acetate (×2), and the combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified on a preparative TLC plate to give the title compound as a colorless solid (16 mg).

Provenance & Evidence