HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 11254641 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Product | (S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 9823314 | — |
Reaction Steps
The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 1,2,3,4-tetrahydroisoquinoline in ethanol essentially as described above in Example 21. Purity by LC/MS=98%, [M+H]+=419.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-048dda65d4d14529a240203862be4073 |
| Source note | uspto-grants-2007_08 |