HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Fluorophenoxy)piperidine → (S)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-[4-(4-fluoro-phenoxy)-piperidin-1-yl]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Fluorophenoxy)piperidine | HCID 3734896 | — |
| Reactant | (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 11254641 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-[4-(4-fluoro-phenoxy)-piperidin-1-yl]-propan-2-ol | HCID 9869771 | — |
Reaction Steps
The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 4-(4-fluoro-phenoxy)-piperidine (Table No.1, SM 5) in ethanol essentially as described above in Example 21. Purity by LC/MS=88%, [M+H]+=481.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-098601366e9d4ed3bffbe89f81d8b701 |
| Source note | uspto-grants-2007_08 |