1,1-Dichloroethane → (R)-1-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-(indan-1-ylamino)-propan-2-ol

HRID 852142Notes

Reaction equation

HRID 852142 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)[CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.Cl[CH:23](Cl)[CH3:24]>NC1C2C(=CC=CC=2)CC1.C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=3)[O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:7][CH:6]3[C:23]4[C:24](=[CH:3][CH:2]=[CH:21][CH:20]=4)[CH2:4][CH2:5]3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 63651,1-DichloroethaneHCID 58928264(R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 9953807(R)-1-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-(indan-1-ylamino)-propan-2-ol

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 123445(+-)-1-AminoindanSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, 1-aminoindan and ethanol, essentially as described above in Example 57. Purity by LC/MS=91%, [M+H]+=419.

Sources & evidence

ORD record
ord-f1aa8b13a4414c048b9b879403a4416f
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

Loading…