HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole → (R)-1-benzylamino-3-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 58928264 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Solvent | Benzylamine | HCID 7504 | — |
| Product | (R)-1-benzylamino-3-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 9821870 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, benzylamine and ethanol, essentially as described above in Example 57. Purity by LC/MS=88%, [M+H]+=393.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-bb44c35f0b564186a46548ff3fe4a5f0 |
| Source note | uspto-grants-2007_08 |