HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (R)-1-(4-chloro-benzylamino)-3-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1,1-Dichloroethane | HCID 6365 | — |
| Reactant | (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 58928264 | — |
| Solvent | 4-Chlorobenzylamine | HCID 66036 | — |
| Product | (R)-1-(4-chloro-benzylamino)-3-[3-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 9910367 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, 4-chlorobenzylamine, and ethanol, essentially as described above in Example 57. Purity by LC/MS=95%, [M+H]+=427.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-6d02f4c95e4b4a8499c329dab08d2ca1 |
| Source note | uspto-grants-2007_08 |