Ethanol → HCID 9931384, compound

HRID 852150Notes

Reaction equation

HRID 852150 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)[CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.C(O)C.[C:25]1([CH2:31][CH2:32][NH2:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1>ClC(Cl)C>[C:25]1([CH2:31][CH2:32][NH:33][CH2:19][C@@H:17]([OH:18])[CH2:16][O:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([C:6]3[C:5]4[CH:20]=[CH:21][C:2]([F:1])=[CH:3][C:4]=4[O:8][N:7]=3)[CH:10]=2)[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 769382-(1-Cyclohexenyl)ethylamineHCID 58928264(R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 9931384HCID 9931384, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, 2-(1-cyclohexenyl)ethylamine, and ethanol, essentially as described above in Example 57. Purity by LC/MS-80%, [M+H]+=411.

Sources & evidence

ORD record
ord-331fb4cb891e4e0692d399821b142584
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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