HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (r)-1-{3-[3-(6-Fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-2-hydroxy-propylamino}-indan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| Reactant | (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 58928264 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | (r)-1-{3-[3-(6-Fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-2-hydroxy-propylamino}-indan-2-ol | HCID 69417536 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-6-fluoro-3-(3-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dichloroethane, (1S, 2R)-(−)-cis-1-amino-2-indanol, and ethanol, essentially as described above in Example 57. Purity by LC/MS=100%, [M+H]+=435.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-9f84fb8a89bb4d1486644856a2da4ef5 |
| Source note | uspto-grants-2007_08 |