HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Chlorophenoxy)piperidine → (R)-1-[4-(3-chloro-phenoxy)-piperidin-1-yl]-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Chlorophenoxy)piperidine | HCID 2735317 | — |
| Reactant | (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 58928269 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-1-[4-(3-chloro-phenoxy)-piperidin-1-yl]-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 58928277 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 4-(3-chlorophenoxy)-piperidine (Table No.1, SM 7) in ethanol, essentially as described above in Example 70. Purity by LC/MS=100%, [M+H]+=497.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-c5b8e3de39e744a79b0461fc05c05c96 |
| Source note | uspto-grants-2007_08 |