2,6-Difluorobenzylamine → HCID 9954157, compound

HRID 852178Notes

Reaction equation

HRID 852178 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]2[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]3[CH2:14][O:13]3)=[CH:8][CH:7]=2)[C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2.[F:21][C:22]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:23]=1[CH2:24][NH2:25]>C(O)C>[S:1]1[CH:5]=[C:4]([C:6]2[CH:16]=[CH:15][C:9]([O:10][CH2:11][C@H:12]([OH:13])[CH2:14][NH:25][CH2:24][C:23]3[C:22]([F:21])=[CH:29][CH:28]=[CH:27][C:26]=3[F:30])=[CH:8][CH:7]=2)[C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2

Participants

4

Reactant 2

HCID 1235632,6-DifluorobenzylamineHCID 17906295HCID 17906295, compound

Product 1

HCID 9954157HCID 9954157, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound is prepared from a mixture of 2-(4-benzo[b]thiophen-3-yl-phenoxymethyl)-oxirane, 2,6-difluorobenzylamine and ethanol essentially as described above in Example 94. Purity by LC/MS=99%, [M+H]+=426.

Sources & evidence

ORD record
ord-cfa1edc5920b4feab63a153cd46fed88
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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