1,2,3,4-Tetrahydroisoquinoline → HCID 9931687, compound

HRID 852181Notes

Reaction equation

HRID 852181 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]2[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]3[CH2:14][O:13]3)=[CH:8][CH:7]=2)[C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2.[CH2:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23][NH:22]1>C(O)C>[S:1]1[CH:5]=[C:4]([C:6]2[CH:16]=[CH:15][C:9]([O:10][CH2:11][C@H:12]([OH:13])[CH2:14][N:22]3[CH2:23][CH2:24][C:25]4[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:21]3)=[CH:8][CH:7]=2)[C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2

Participants

4

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 17906295HCID 17906295, compound

Product 1

HCID 9931687HCID 9931687, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound is prepared from a mixture of 2-(4-benzo[b]thiophen-3-yl-phenoxymethyl)-oxirane, 1,2,3,4-tetrahydroisoquinoline and ethanol essentially as described above in Example 94. Purity by LC/MS=100%, [M+H]+=416.

Sources & evidence

ORD record
ord-d28029e872b74e858f86467db7efb0fe
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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