HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (R)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine | HCID 58928270 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Product | (R)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-propan-2-ol | HCID 58928283 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine in dimethylformamide and ethanol and 1,2,3,4-tetrahydroisoquinoline in ethanol essentially as described above in Example 102. Purity by LC/MS=100%, [M+H]+=402.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-36d1766d6f1f4d139e5a462adb65508f |
| Source note | uspto-grants-2007_08 |