HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyrimidinyl)piperazine → (R)-1-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-3-(4-pyrimidin-2-yl-piperazin-1-yl)-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Reactant | (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine | HCID 58928270 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-1-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-3-(4-pyrimidin-2-yl-piperazin-1-yl)-propan-2-ol | HCID 58928310 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine in dimethylformamide and ethanol and 2-piperazin-1-yl-pyrimidine in ethanol essentially as described above in Example 102. Purity by LC/MS=100%, [M+H]+=433.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-abf2464674ac408b8922092a71ee2ef7 |
| Source note | uspto-grants-2007_08 |